John W. Scott
Research Interests:
Neurobiology of the olfactory system.
The research in this laboratory concerns the functional organization of the
olfactory epithelium and olfactory bulb in the rat and mouse. We are mapping
the distribution of olfactory epithelium sensitivity to odorants of particular
chemical classes and are interested in how this distribution may participate in
the neural interpretation of olfactory stimuli. We also study the synaptic
organization of the olfactory bulb, the first order synapse of the olfactory
receptor axons. We have described different groups of projection cells and
inhibitory interneurons that have distinct
physiological properties as well as anatomical connections. We have used
intracellular recording and dye marking to test how these different cell groups
participate in sensory coding.
A
recent interest is the effect of chemical properties of odorants on the
localization of responses in the olfactory epithelium and olfactory bulb as
well as on the response to air flow in the nose. Our most recent work of this nature is on the
differences in response to the same odorant when it enters the nose from the
external vs. internal nares.
Selected publications.
Scott
JW and Sherrill, L. Effects of Odor Stimulation on Antidromic Spikes in Olfactory Sensory NeuronsJ.
Neurophysiol. 100: 3074-3085, 2008.
Scott
JW, Acevedo HP, Sherrill L. and Phan, M. Responses of the Rat
Olfactory Epithelium to Retronasal Air Flow. J.
Neurophysiol. 97: 1941-1950, 2007.
Scott JW, Acevedo HP, and Sherrill L. Effects of concentration and sniff flow rate on the rat electroolfactogram. Chemical Senses. 31:581-593, 2006.
Scott,
J. W. Sniffing and
spatiotemporal coding in olfaction.
Chemical Senses. 31:119-30, 2006.
Scott, J.W. and Scott-Johnson, P.E. The Electroolfactogram: A Review of Its History and Uses. Microscopy Research and
Technique. 58: 152-160,2002.
Scott-Johnson, P. E., Blakley,
D., and Scott, J. W. Effects of Air Flow and on Rat Electroolfactogram. Chemical Senses,
25:761-768, 2000
Scott, J. W., Brierley,
T. and F. H. Schmidt. Chemical determinants of the rat electroolfactogram. J. Neuroscience 20:4721-4731, 2000.
Scott, J. W. and Brierley,
T. A functional map in
rat olfactory epithelium.
Chemical Senses. 24: 679-690, 1999.
Scott, J.W., Shannon, D.E., Charpentier,
J.,
Buiakova,
O. I., Baker, H., Scott, J.W., Farbman, A., Kream, R., Grillo, M., Franzen,
L., Richman, M., Davis, L.M., Abbondanzo,
S., Stewart, C.L., and Margolis, F. L.
Olfactory marker protein (OMP) gene deletion causes altered
physiological activity of olfactory sensory neurons. Proc. Nat. Acad. Sci.
USA 93:9858-9863, 1996.
Scott, J.W.,
Ezeh, P.I., L.M. Davis, and J.W. Scott. Regional distribution of
rat electroolfactogram. J. Neurophysiol. 73:2207-2220, 1995.
Scott, J.W., S. J. Zottoli,
N. P. Beatty, and H. Korn. Origin and function of spiral
fibers
projecting to the goldfish mauthner cell. J. Comp. Neurol. 339:76-90, 1994.
Ezeh, P.I., D.P. Wellis and J.W.
Scott. Organization of inhibition in the rat olfactory bulb external plexiform layer.
J. Neurophysiol. 70:263-274, 1993.
Scott, J.W., D.P. Wellis,
M.J. Riggott, and N. Buonviso.
Functional organization of the main olfactory bulb.
Microscopy Research and technique 24:142-156, 1993.
Wellis,
D.P. and J.W. Scott. Intracellular responses of identified rat olfactory bulb interneurons to electrical and odor stimulation. J. Neurophysiol. 64:932-947, 1991.
Wellis,
D.P. and J.W. Scott. Localized denervation
demonstrates the innervation pattern of olfactory
bulb glomeruli and second order cells. J. Comp. Neurol. 304:544-554, 1991.
Buonviso,
N., M. Chaput, and J.W. Scott.
Mitral cell-to-glomerulus
connectivity: an HRP study of the orientation of mitral
cell apical dendrites. J. Comp. Neurol. 307:57-64,
1991.
Scott, J.W. Central processing of Olfaction
Proceedings of the international Symposium on Recent Advances in Mammalian
Pheromone Research. (D.L. Berliner, R.P.
Michael & J.R. Pasqualine eds) J. Ster. Biochem. & Mol. Biol.
39: 593:600, 1991.
Wellis,
D.P., J.W. Scott and T.A. Harrison Discrimination among odorants by
single neurons of the rat olfactory bulb.
Journal of Neurophysiology, 61:1161-1177, 1989.
Mouradian, L.E. and J.W. Scott. Cytochrome oxidase staining marks dendritic
zones of the rat olfactory bulb external plexiform
layer. J. Comp. Neurol.
271:507-518, 1988.
Scott, J.W., J.K. McDonald and J.L.
Pemberton. Short
axon cells of the rat olfactory bulb display NADPH-diaphorase
activity, neuropeptide Y-like immunoreactivity
and somatostatin-like immunoreactivity. J. Comp. Neurol. 260:378-391, 1987.
Scott, J.W. and T.A. Harrison. The main olfactory bulb;
anatomy and physiology. In: The
Olfactory System, W. Silver and T. Finger (eds.), pp. 151-178. John Wiley & Sons,
1986.
Scott, J.W., E.C. Rainer, J.L. Pemberton,
E. Orona and L.E. Moradian.
Pattern of rat olfactory bulb mitual and tufted cell
projections to anterior olfactory nucleus pars externa.
J. Comp Neurol. 242:415-424, 1985.
Scott, J.W., E.C. Rainer, J.L. Pemberton,
E. Orona and L.E. Moradian.
Pattern of rat olfactory bulb mitual and tufted cell
projections to anterior olfactory nucleus pars externa.
J. Comp Neurol. 242:415-424, 1985.
Orona, E., E.C. Rainer and J.W. Scott. Dentritic and axonal organization of mitral and
tufted cells in the rat olfactory bulb.
J. Comp. Neurol. 226:346-356, 1984.
Schneider, S.P. and J.W. Scott. The orthodromic
response properties of rat olfactory bulb mitral and
tufted cells correlate with their projection patterns. J. Neurophysiol.
50:358-378, 1983.
Orona, E., J.W. Scott and E.C. Rainer. Different granule cell populations innervate
superficial and deep regions of the external plexiform
layer in rat olfactory bulb. J. Comp. Neurol.
217:227-237, 1983.
Scott, J.W. Electrophysiological identification of mitral and tufted cells and the distributions of their axons in the olfactory system of the rat. J. Neurophysiol. 46:918-931, 1981.