Professor of Cell Biology
Associate Professor of Rehabilitation Medicine
Affiliate Scientist, Yerkes Regional Primate Research Center
Ph.D., University of Illinois, 1974
Program: Neuroscience (NS)
The main interest in my laboratory is enhancing functional recovery following injury to the peripheral nervous system. Peripheral nerve injuries are common clinically but functional recovery from them is rare. Following nerve injury, denervated muscles are deprived of neural control and sensory feedback regulating muscle function is lost. In addition, synaptic inputs onto spinal motoneurons are withdrawn. The slow growth of regenerating axons and the slow reformation of synapses, both in the periphery and in the CNS, are the reasons given for poor functional outcomes. We have found that exercise or electrical stimulation enhances the growth of regenerating axons. Using a combination of transgenic and knockout mice we are investigating the roles played by the neurotrophins BDNF and NT-4/5 in that enhancement, as well as in the reformation of synapses at both neuromuscular junctions and spinal motoneurons. Using chronic electrophysiologic recordings in rats, we are evaluating the effects of exercise or electrical stimulation on functional recovery following peripheral nerve injury.
Sabatier, M.J., Redmon, N., Schwartz, G. and English, A.W., Treadmill training promotes axon regeneration in injured peripheral nerves. Exp. Neurol. 211: 489–493, 2008
English, A.W., Cucoranu, D., Mulligan, A., and Sabatier, M.J., Treadmill training enhances axon regeneration in injured mouse peripheral nerves without increased loss of topographic specificity. J. Comp. Neurol., 517:245-255, 2009
Sabatier, M.J., To, B.N., Nicolini, J., and English, A.W., Effect of axon misdirection on recovery of EMG activity and kinematics after peripheral nerve injury. Cells Tissues Organs, In Presss, 2011
Hamilton SK, Hinkle ML, Kaufman MR, Jennifer Nicolini J, Rambo L, Rexwinkle AR, Rose SR, Sabatier MJ, Backus D, English AW. Misdirection of regenerating axons has little effect on functional recovery following sciatic nerve injury in rats. J Comp Neurol 259: Jan. 2011.
Sabatier, M.J., To, B.N., and English, A.W., Effect of slope and sciatic nerve injury on ankle muscle recruitment and hindlimb kinematics during walking in the rat. J. Exp. Biol. IN PRESS, 2011
English, A.W., Cucoranu, D., Mulligan, A., and Sabatier, M.J., Neurotrophin-4/5 is implicated in the enhancement of axon regeneration following peripheral nerve injury produced by treadmill training. Eur. J. Neurosci. Under Review, 2010
Willis, D.E., Donnelly, C.J., Xu, M., Tep, C., Kendall, M., Erenstheyn, M., English, A., Schanen, N.C., Kirn-Safran, C., Yoon, S.O., Bassell, G., Twiss, J.L. Axonal synthesis of b-actin protein facilitates nerve regeneration in vivo. Neuron., under review, 2010.
Krakowiack, J., Wilhelm, J.C., and English, A.W. Effect of treadmill training on synaptic stripping of axotomized mouse motoneurons. J Comp. Neurol, Submitted, 2010.